Frédéric Austerlitz (en)
CR2 CNRS
Monday 4 August 2008, by Frédéric Austerlitz
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| CNRS Researcher
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| Research | Teaching | Students | Curriculum Vitae | Software | Publications |
Resarch activities
I am mainly interested in theoretical population genetics. My research deals with the impact of demographic and selective processes on genetic diversity, and conversely on the estimation of the intensity of these processes using population genetics data. In particular I have developed methods for the estimation of pollen dispersal in plants, both in the context of forest research and in the context of transgene dispersal. I have also developed methods to infer demographic, cultural and selective processes from genetic data in humans. Finally I am currently developing models for the study of the evolution of regulation in genetic networks under various conditions.
Teaching activities
| 2006 – | Teaching « Mathematics in Plant Biology » organised at the University of Wageningen (Holland) by the dutch graduate schools "Experimental Plant Sciences" (E.P.S.), "Plant Ecology and Resource Conservation" (PE&RC) and the French graduate schools "Science du Végétal" (SdV) and ABIES en France. Teaching and computer practical on modeling in population genetics (3 hours). Teaching perfomed in English. Enseignement effectué en anglais qui va se transformer en formation erasmus. |
| 2005 – | Master 2nd year « Human Evolution» (3 hours per year). Demographic processes and genetic diversity in humans. (in French) |
| 2005 – | Master 2nd year« Multifactorial Genetics » (3 hours per year). Methods for detecting adaptive processes from genetic data. (in French) |
| 2004 – | Master 2nd year « Population Genomics » (3 to 9 hours per year). Advanced coalescent theory, methods for estimating demographic parameters from genetic data (with practical on computer). (in French) |
| 2004 – | Master 1st année Ecole Normale Supérieure (6 hours per year). Bases, Théories de la coalescence, FST. (in French) |
| 2002 – 2006 | Population Genetics (3 hours per year) at I.N.A.-P.G (1st year). Théorie de la coalescence. (in French) |
| 1997 – 2003 (sauf 1999) | Population Genetics (3 hours per year ) in the master « Biodiversity, Génétics and Evolution » (Universities Paris VI, VII, XI, I.N.A.-P.G., M.N.H.N.). Coalescent theory. (in French) |
| 1996 – 1998 | Population Genetics (E.N.G.R.E.F., 1st year) (3 to 6 hours per year). Bases and coalescent theory. (in French) |
Students
Ecole Polytechnique (3rd year) : Adrien Franchini (2006).
Ecole Normale Supérieure (2nd year) : Alexandra Carpentier (2003).
Master degree (2nd year). : Co-superviser of d’Etienne Klein (1995-1996) and Raphaëlle Chaix (2000-2001), full superviser of Julien Guglielmini (2004-2005) and Isabelle Giraud (2004-2005).
PhD thesis: Raphaëlle Chaix (50%, 2001-2004) and Michaël Blum (50%, 2002-2005).
Internship of J.J. Robledo Arnuncio (PhD student, INIA Madrid, Spain). 3 month (2004).
Curriculum vitae
| 2005 | Habilitation à Diriger les Recherches (Specific French diploma allowing to supervise PhD Students). Diploma delivered by Université Paris-Sud. |
| 2002 – | Permanent CNRS Researcher. Laboratoire ESE, Université de Paris-Sud (Orsay, France). |
| 2000 – 2002 | Researcher at the Laboratoire de Génétique et Amélioration des Arbres Forestiers (Dir. Antoine Kremer) INRA Bordeaux (France). |
| 1999 – 2000 | Postdoctoral fellow. Rutgers University (New Brunswick, NJ, USA). (Supervisor Pr P.E. Smouse). Subject: “Estimation of instantaneous pollen flow”. |
| 1995 – 1999 | PhD thesis in population genetics at the Université de Paris-Sud (Orsay, France). Subject: “On the impact of demographic processes on genetic diversity”. (Supervisors Pr P.-H. Gouyon and Dr E. Heyer) |
| 1994 – 1995 | D.E.A. (Master Degree) in Biodiversity, Genetics and Evolution. Université Paris-Sud. Internship (6 months). Subject “Evolution of coalescent times during colonization” (Supervisor: Pr Pierre-Henri Gouyon). |
| 1993 – 1995 | Ecole du Génie Rural des Eaux and Forets (French school for water, Forests and Environment Engineering). Internship at UC Berkeley (1.5 months). Subject: “Coalescent theory in logistically growing populations” (Supervisor: Pr Montgomery Slatkin). |
| 1990 – 1993 | Ecole Polytechnique (Polytechnic School). Internship at INRA Versailles (3 months). Subject: “Gene tagging using transposable elements in Nicotiana Plumbaginifolia”. (Supervisor: Dr Annie Marion-Poll, INRA Versailles) |
Software
Poldisp: a software package for indirect estimation of contemporary pollen dispersal.
Publications
BARLUENGA M., AUSTERLITZ F., ELZINGA J. A., TEIXEIRA S., GOUDET J., BERNASCONI G. 2010. Fine-scale spatial genetic structure and gene dispersal in Silene latifolia. Heredity (sous presse).
HEYER E., AUSTERLITZ F. 2010. Update to Heyer's "One founder-one gene hypothesis in a new expanding population". Human Biology (sous presse).
SOUFIR N., GED C., BOURILLON A., AUSTERLITZ F., CHEMIN C., STARY A., ARMIER J., PHAM D., KHADIR K., ROUME J., HADJ RABIA S., BOUADJAR B., TAIEB A., DE VERNEUIL H., BENCHIKI H., GRANDCHAMP B., SARASIN A. 2010. A prevalent mutation with founder effect in xeroderma pigmentosum group C from North Africa. Journal of Investigative Dermatology (sous presse).
MINDER E. I., SCHNEIDER-YIN X., MAMET R., HOREV L., NEUENSCHWANDER S., BAUMER A., AUSTERLITZ F., PUY H., SCHOENFELD N. 2010. A homoallelic FECH mutation in a patient with both erythropoietic protoporphyria and palmar keratoderma. Journal of the European Academy of Dermatology and Venereology (sous presse).
VERDU P., AUSTERLITZ F., ESTOUP A., VITALIS R., GEORGES M., THERY S., FROMENT A., LE BOMIN S., GESSAIN A., HOMBERT J., VAN DER VEEN L., QUINTANA-MURCI L., BAHUCHET S., HEYER E. 2009. Origins and genetic diversity of pygmy hunter-gatherers from Western Central Africa. Current Biology 19. 312–318.
AUSTERLITZ F., DAVID O., SCHAEFFER B., BLEAKLEY K., OLTEANU M., LEBLOIS R., VEUILLE M., LAREDO C. 2009. DNA barcode analysis: a comparison of phylogenetic and statistical classification methods. BMC Bioinformatics 10 (Suppl 14). S10.
CHAIX R., AUSTERLITZ F., HEGAY T., QUINTANA-MURCI L., HEYER E. 2008. Genetic traces of east-to-west human expansion waves in Eurasia. American Journal of Physical Anthropology 136. 309–317.
LLAURENS V., CASTRIC V., AUSTERLITZ F., VEKEMANS X. 2008. High paternal diversity in the self-incompatible herb Arabidopsis halleri despite clonal reproduction and spatially restricted pollen dispersal. Mol Ecol 17.6. 1577–1588. 1365-294X (Electronic).
MAGALON H., PATIN E., AUSTERLITZ F., HEGAY T., ALDASHEV A., QUINTANA-MURCI L., HEYER E. 2008. Population genetic diversity of the NAT2 gene supports a role of acetylation in human adaptation to farming in Central Asia. European Journal of Human Genetics 16.2. 243–251.
TENAILLON M. I., AUSTERLITZ F., TENAILLON O. 2008. Apparent mutational hotspots and long distance linkage disequilibrium resulting from a bottleneck. J Evol Biol 21.2. 541–550. 1420-9101 (Electronic).
AQUARON R., SOUFIR N., BERGE-LEFRANC J., BADENS C., AUSTERLITZ F., GRANDCHAMP B. 2007. Oculocutaneous albinism type 2 (OCA2) with homozygous 2.7-kb deletion of the P gene and sickle cell disease in a Cameroonian family. Identification of a common TAG haplotype in the mutated P gene. Journal of Human Genetics 52.9. 771–780. 1434-5161.
AUSTERLITZ F., DUTECH C., SMOUSE P. E., DAVIS F., SORK V. L. 2007. Estimating anisotropic pollen dispersal: a case study in Quercus lobata. Heredity 99.2. 193–204. 0018-067X.
CHAIX R., QUINTANA-MURCI L., HEGAY T., HAMMER M. F., MOBASHER Z., AUSTERLITZ F., HEYER E. 2007. From social to genetic structures in central Asia. Curr Biol 17.1. 43–48. 0960-9822 (Print).
DEVAUX C., LAVIGNE C., AUSTERLITZ F., KLEIN E. K. 2007. Modelling and estimating pollen movement in oilseed rape (Brassica napus) at the landscape scale using genetic markers. Molecular Ecology 16.3. 487–499. 0962-1083.
FENART S., AUSTERLITZ F., CUGUEN J., ARNAUD J. F. 2007. Long distance pollen-mediated gene flow at a landscape level: the weed beet as a case study. Molecular Ecology 16.18. 3801–3813. 0962-1083.
ROBLEDO-ARNUNCIO J. J., AUSTERLITZ F., SMOUSE P. E. 2007. POLDISP: a software package for indirect estimation of contemporary pollen dispersal. Molecular Ecology Notes 7.5. 763–766. 1471-8278.
BLUM M. G. B., HEYER E., FRANÇOIS O., AUSTERLITZ F. 2006. Matrilineal fertility inheritance detected in hunter-gatherer populations using the imbalance of gene genealogies. PLoS Genetics 2.8. e122.
GOUYA L., MARTIN-SCHMITT C., ROBREAU A. M., AUSTERLITZ F., SILVA V. D., BRUN P., SIMONIN S., LYOUMI S., GRANDCHAMP B., BEAUMONT C., PUY H., DEYBACH J. C. 2006. Contribution of a common single-nucleotide polymorphism to the genetic predisposition for erythropoietic protoporphyria. American Journal of Human Genetics 78.1. 2–14.
ODDOU-MURATORIO S., KLEIN E. K., DEMESURE-MUSCH B., AUSTERLITZ F. 2006. Real-time patterns of pollen flow in the wildservice tree, Sorbus torminalis (rosaceae) III. Mating patterns and the ecological maternal neighborhood. American Journal of Botany 93.11. 1650–1659.
PATIN E., BARREIRO L. B., SABETI P. C., AUSTERLITZ F., LUCA F., SAJANTILA A., BEHAR D. M., SEMINO O., SAKUNTABHAI A., GUISO N., GICQUEL B., MCELREAVEY K., HARDING R. M., HEYER E., QUINTANA-MURCI L. 2006. Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes. Am J Hum Genet 78.3. 423–436.
ROBLEDO-ARNUNCIO J. J., AUSTERLITZ F. 2006. Pollen dispersal in spatially aggregated populations. American Naturalist 168.4. 500–511. 0003-0147.
ROBLEDO-ARNUNCIO J. J., AUSTERLITZ F., SMOUSE P. E. 2006. A new method of estimating the pollen dispersal curve independently of effective density. Genetics 173.2. 1033–1045.
GÉRARD P. R., KLEIN E. K., AUSTERLITZ F., FERNANDEZ-MANJARRES J. F., FRASCARIA-LACOSTE N. 2006. Assortative mating and differential male mating success in an ash hybrid zone population. Bmc Evolutionary Biology 6. 1471-2148.
GIRAUD T., VILLAREAL L. M., AUSTERLITZ F., LE GAC M., LAVIGNE C. 2006. Importance of the life cycle in sympatric host race formation and speciation of pathogens. Phytopathology 96.3. 280–287. 0031-949X (Print).
AUSTERLITZ F. 2005. Impact des processus démographiques et sélectifs sur la diversité génétique. HDR . Orsay: Université Paris-Sud.
HEYER E., SIBERT A., AUSTERLITZ F. 2005. Cultural transmission of fitness: genes take the fast lane. Trends in Genetics 21.4. 232–237.
ODDOU-MURATORIO S., KLEIN E. K., AUSTERLITZ F. 2005. Pollen flow in the wildservice tree, Sorbus torminalis (L.) Crantz. II. Pollen dispersal and heterogeneity in mating success inferred from parent-offspring analysis. Mol Ecol 14.14. 4441–4452.
AUSTERLITZ F., DICK C. W., DUTECH C., KLEIN E. K., ODDOU-MURATORIO S., SMOUSE P. E., SORK V. L. 2004. Using genetic markers to estimate the pollen dispersal curve. Molecular Ecology 13. 937–954.
CHAIX R., AUSTERLITZ F., KHEGAY T., JACQUESSON S., HAMMER M. F., HEYER E., QUINTANA-MURCI L. 2004. The genetic or mythical ancestry of descent groups: lessons from the Y chromosome. Am J Hum Genet 75.6. 1113–1116.
CHAIX R., AUSTERLITZ F., MORAR B., KALAYDJIEVA L., HEYER E. 2004. Vlax Roma history: what do coalescent-based methods tell us? European Journal of Human Genetics 12.4. 285–292. 1018-4813 (Print).
DICK C. W., ETCHELECU G., AUSTERLITZ F. 2003. Pollen dispersal of tropical trees (Dinizia excelsa: Fabaceae) by native insects and African honeybees in pristine and fragmented Amazonian rainforest. Mol Ecol 12.3. 753–764.
MACHON N., BARDIN P., MAZER S. J., MORET J., GODELLE B., AUSTERLITZ F. 2003. Relationship between genetic structure and seed and pollen dispersal in the endangered orchid Spiranthes spiralis. New Phytologist 157. 677–687.
ODDOU-MURATORIO S., HOUOT M. .-L., DEMESURE-MUSH B., AUSTERLITZ F. 2003. Pollen flow in the wildservice tree, Sorbus torminalis (L.) Crantz. I. Evaluating the paternity analysis procedure in continuous populations. Molecular Ecology 12. 3427–3439.
AUSTERLITZ F., GARNIER-GERE P. H. 2003. Modelling the impact of colonisation on genetic diversity and differentiation of forest trees: interaction of life cycle, pollen flow and seed long-distance dispersal. Heredity 90.4. 282–290. 0018-067X (Print).
AUSTERLITZ F., KALAYDJIEVA L., HEYER E. 2003. Detecting population growth, selection and inherited fertility from haplotypic data in humans. Genetics 165.3. 1579–1586. 0016-6731 (Print).
FERDY J.-B., AUSTERLITZ F. 2002. Extinction and introgression in a community of partially cross-fertile plant species. American Naturalist 160. 7486.
HUNTER M., HEYER E., AUSTERLITZ F., ANGELICHEVA D., NEDKOVA V., BRIONES P., GATA A., DE PABLO R., LASZLO A., BOSSHARD N., GITZELMANN R., TORDAI A., KALMAR L., SZALAI C., BALOGH I., LUPU C., CORCHES A., POPA G., PEREZ-LEZAUN A., KALAYDJIEVA L. V. 2002. The P28T mutation in the GALK1 gene accounts for galactokinase deficiency in Roma (Gypsy) patients across Europe. Pediatr Res 51.5. 602–606.
MARIETTE S., LE CORRE V., AUSTERLITZ F., KREMER A. 2002. Sampling within the genome for measuring within-population diversity: trade-offs between markers. Molecular Ecology 11. 1145–1156.
SIBERT A., AUSTERLITZ F., HEYER E. 2002. Wright-Fisher revisited: the case of fertility correlation. Theoretical Population Biology 62. 181–197.
AUSTERLITZ F., SMOUSE P. E. 2002. Two-generation analysis of pollen flow across a landscape. IV. Estimating the dispersal parameter. Genetics 161.1. 355–363. 0016-6731 (Print).
AUSTERLITZ F., SMOUSE P. E. 2001. Two-generation analysis of pollen flow across a landscape. II. Relation between phi(ft), pollen dispersal and interfemale distance. Genetics 157.2. 851–857. 0016-6731 (Print).
AUSTERLITZ F., SMOUSE P. E. 2001. Two-generation analysis of pollen flow across a landscape. III. Impact of adult population structure. Genet Res 78.3. 271–280. 0016-6723 (Print).
AUSTERLITZ F., MARIETTE S., MACHON N., GOUYON P.-H., GODELLE B. 2000. Effects of colonization processes on genetic diversity: differences between annual plants and tree species. Genetics 154.3. 1309–1321.
AUSTERLITZ F., HEYER E. 2000. Allelic association is increased by correlation of effective family size. European Journal of Human Genetics 8. 980–985.
AUSTERLITZ F., BRACHET S., COUVET D., FRASCARIA-LACOSTE N., JUNG-MULLER B., KREMER A., STREIFF R. 1999. Flux génétiques chez les arbres forestiers Synthèse bibliographique. Paris: Commission des Ressources Génétiques Forestières.
AUSTERLITZ F., HEYER E. 1999. Impact of demographic distribution and population growth rate on haplotypic diversity linked to a disease gene and their consequences for the estimation of recombination rate: example of a French Canadian population. Genet Epidemiol 16.1. 2–14. 0741-0395 (Print).
KLEIN E. K., AUSTERLITZ F., LAREDO C. 1999. Some statistical improvements for estimating population size and mutation rate from segregating sites in DNA sequences. Theor Popul Biol 55.3. 235–247. 0040-5809 (Print).
FERDY J. B., AUSTERLITZ F., MORET J., GOUYON P., GODELLE B. 1999. Pollinator-induced density dependence in deceptive species. Oikos 87.3. 549–560. 0030-1299.
AUSTERLITZ F., BRACHET S., COUVET D., FRASCARIA-LACOSTE N., JUNG-MULLER B., KREMER A., STREIFF R. 1999. Flux génétiques chez les arbres forestiers Synthèse bibliographique Commission Ressources Génétiques Forestières. Collection.
GODELLE B., AUSTERLITZ F., BRACHET S., COLAS B., CUGUEN J., GANDON S., GOUYON P.-H., LEFRANC M., OLIVIERI I., REBOUD X., VITALIS R. 1998. Système génétique, poLymorphisme neutre et sélectionné: implications en biologie de la conservation. In Genet. Sel. Evol.. (30(Suppl. 1)). 15–28.
AUSTERLITZ F., HEYER E. 1998. Social transmission of reproductive behavior increases frequency of inherited disorders in a young-expanding population. Proc Natl Acad Sci U S A 95.25. 15140–15144. 0027-8424 (Print).
AUSTERLITZ F., JUNGMULLER B., GODELLE B., GOUYON P. 1997. Evolution of coalescence times, genetic diversity and structure during colonization. Theoretical Population Biology 51.2. 148–164. 0040-5809.